I'm dying to know what happens/happened with all the Pokemon that Ash left behind or gave to other trainers. Remember his Mankey/Primeape, Pidgeot, Butterfree, Charizard, Squirtle? Perhaps Misty's Togetic? There's probably more that I don't remember...I wonder if Ash would get them back, or at least see them again.
The next biggest thing I wonder is what the heck went wrong between Brock and Prof. Ivy.
And Tracey. Is he going to switch back in sometime soon?
Another thing I've wondered is when Max is going to get his first Pokemon, and what it's going to be. But I guess that's a moot question now that Max is gone...
Oh, and the GS ball. What is it all about???
I often wonder about Jessie and James's family. They talk about them occasionally, but they are always vague about them.
and one dumb, but sincere and honest, question: Is Brock ever going to open his eyes?
... and I guess that's all the questions I have right now.