If you haven't played a Metroid Prime game before, you should get the Metroid Prime Trilogy. All three Metroid Prime games in one and is an amazing package overall.
Bioshock 2
Dragon Age Origins
Final Fantasy 13
Prototype (highly underrated game)
Resident Evil 5
Fallout 3
Mass Effect 2
Uncharted 2: Among Thieves
Call of Duty: Modern Warfare 2
Assassin's Creed 2
Halo 3 ODST
Red Faction: Guerrilla
Final Fantasy III
Final Fantasy IV
Final Fantasy XII: Revenant Wings
Gears of War 2
LOST: Via Domus
Wait until Super Mario Galaxy 2
Wait until Red Dead Redemption
There are a lot of good games out there. Depends on what you like.