If you have the ability to play both Hex Maniac and Ghetsis on the first turn going first, which one would you go with? Both have merit. You could play Hex Maniac so that your opponent definitely can't play any Shaymin, or you could take a chance with Ghetsis and potentially cripple your opponent right out of the gate. The drawback to playing Ghetsis is that you don't know how many Items are in your opponent's hand until you play it, or whether or not you'd actually be doing your opponent a favor by shuffling back in 3 VS Seekers and leaving them with a Juniper or a Shaymin. I played against Blastoise and couldn't decide which one to go for, so I played Ghetsis and got rid of a Battle Compressor, VS Seeker, and some other stuff, leaving them with one Water Energy.