In that context "You, sir, are evil", it can apply to a person of either gender and it's still technically correct.
I get in the habit of replacing 'sir' with 'madam' if I know I'm addressing a female though...that is, if I feel like it. =D
Spoink!, You, sir, are evil. I can't believe you're pretty much spamming up DNA's profile just so that he can beat me. :O He's way ahead of me now. :'(
You certainly have guts, though, I'll give you that. ;D